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Board-certified allergist placing a precise skin-prick testing grid on a patient's inner forearm, each wheal site labeled with printed markers, cool clinical overhead lighting
Supervised Drug Allergy Challenges — San Francisco, CA

Find out what you're
actually allergic to.

Supervised drug challenges. Board-certified allergists.Answers in one visit.

94%of penicillin "allergies" are cleared on challenge
1 visitfrom chart note to signed allergy letter
AAAAIboard-certified allergists on staff
Phase 01

What happens
before you arrive.

The challenge itself is a single morning. The preparation is what makes it safe — and what lets your allergist walk in already knowing your history.

01

Submit your medical records

Upload prior allergy notes, reaction descriptions, or your chart summary. Our clinical team reviews everything before your appointment — no surprises on the day.

02

Complete the drug history questionnaire

A 12-question intake covering the suspected drug, the original reaction, any re-exposures, and current medications. Takes 8 minutes. Completable from your phone.

03

Receive your pre-challenge briefing

Your allergist reviews your file and calls you 48 hours before your appointment to confirm protocol, answer questions, and clear any same-day contraindications.

Clinical intake paperwork and drug history questionnaire on a clean white desk with a physician's pen

Pre-challenge review

Completed 48 hrs before your visit

Your records are reviewed by your allergist — not a triage algorithm.

Every intake is read by the physician who will conduct your challenge. They know your chart before you walk in the door.

Phase 02

What happens
in the room.

A graded oral challenge is not a provocation test. It is a controlled, step-wise administration of increasing doses under continuous clinical supervision — designed to catch any reaction at its earliest and mildest signal.

Challenge Day Protocol — Illustrated Timeline

Live monitoring
0 min
Baseline vitals recorded
15 min
1/100th therapeutic dose administered
30 min
Observation. Vitals every 5 minutes.
45 min
1/10th therapeutic dose administered
60 min
Observation. Skin assessment, BP, SpO₂.
75 min
Full therapeutic dose administered
90 min
Final 60-minute observation period begins
150 min
Results reviewed. Discharge or treatment.

* Protocol may vary based on pre-challenge review findings. Your allergist will confirm your specific schedule.

Continuous cardiac monitoring

Pulse oximetry and ECG throughout the procedure.

Epinephrine on the counter

Not in a cabinet. On the counter. Beside the physician.

Two-clinician protocol

Your allergist and a dedicated RN present for every graded dose.

Graded dose escalation

Starting at 1% of therapeutic dose — not the full amount.

Phase 03

What you leave
with.

A typed, physician-signed allergy status letter — not a handwritten note, not an addendum to your chart. A formal clinical document that travels with you.

Formal allergy status determination

Cleared, confirmed, or inconclusive — with clinical rationale for each finding.

Physician signature and NPI number

Accepted by hospital admissions, pharmacy systems, and surgical pre-op coordinators.

Safe alternative medications listed

If a reaction is confirmed, your letter includes tested-safe alternatives for common procedures.

Electronic copy sent to your PCP

Your primary care physician receives a copy automatically. No faxing required on your end.

ASSAY

Drug Allergy Testing Clinic

Date: February 24, 2026

Ref: ASY-2026-0847

Penicillin Allergy — CLEARED

Patient tolerated full therapeutic dose without reaction.

Dr. M. Okonkwo, MD

AAAAI Board-Certified Allergist · NPI 1234567890

Letter accepted by

UCSF Medical CenterStanford Health CareKaiser PermanenteCVS / WalgreensSurgical Pre-Op TeamsOncology Pharmacies
Schedule

Book your
allergy challenge.

Most appointments are available within 5–10 business days. If you'd prefer to send records before committing to a date, use the secondary path below.

Morning appointments only — challenge days run 9am–1pm

Plan for 3–4 hours. Most patients are discharged by noon.

We accept most PPO plans. Prior auth handled by our team.

Questions? Call (415) 555-0194 — no phone tree.

Your information is transmitted securely and never shared with third parties.
HIPAA-compliant. 256-bit encryption.